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Formerly an ordinary human, Fujiwara no Mokou became an immortal being after drinking the Hourai Elixir roughly 1300 years ago. Now she is unable to die, though she can still feel the pain of injuries as a normal human does. She does not age, she'll never become ill, she is entirely self-sustained (nourishment such as food, water, or sleep does not impact her body at all), every injury she sustains shall cease; critical injuries will be healed in a matter of days. Complete destruction results in an immediate and complete restoration. This makes her completely indestructible, and it extends to her mental and spiritual states just as much as her physical state, as she is shown living a carefree life free of mental exhaustion even after 1300 years. She will never be able to die.
Due to her longevity, Mokou has garnered much experience and is able to endure a high threshold of pain. She is arguably the strongest human in Gensokyo, and her abilities are said to be on par with some of Gensokyo's most elite youkai.
Mokou has a long running history of hatred for Kaguya, sparked by her father's failure (assumed to be Fujiwara no Fuhito) to fulfill an impossible request at the time of his proposal to Kaguya. She also seems annoyed at Kaguya's persistent attempts to kill her, even through non-direct ways (as was the case when the human-youkai team was manipulated by Kaguya to assassinate Mokou after the events of Imperishable Night). Even though it has been over a thousand years since the initial ordeal, she continues to detest Kaguya, knowing full well that she can never get her revenge--nor can Kaguya ever put a permanent end to her. When not fighting with Kaguya though, she aids the nearby villagers by exterminating youkai and will even guide them safely to Eientei for medical treatment. She is a loner by nature and chooses not to socialize with humans or youkai and has a dubious personality that can easily switch from friendly to threatening and back again, but her actions seem to indicate she may be a good person.